Delayed-Release Prednisone Reduces Morning Stiffness

Among RA patients who have had an inadequate response to conventional, immediate-release prednisone, switching to delayed-release prednisone (Rayos®) at bedtime significantly reduced the duration of morning stiffness. These results were presented at the 2013 annual meeting of the American College of Rheumatology.

Steroid drugs such as prednisone can improve RA symptoms, and may be especially useful during a flare-up of symptoms or while waiting for a slower-acting drug (such as the disease-modifying antirheumatic drugs) to take effect.Standard steroid medications are typically taken in the morning and may have limited effect on symptoms that occur early in the day, such as morning stiffness. Delayed-release prednisone can be taken at bedtime and becomes effective a few hours later.

To evaluate the impact of switching from immediate-release prednisone to delayed-release prednisone, researchers evaluated 110 RA patients who were participating in the CAPRA-1 clinical trial. In addition to prednisone, all patients were also being treated with a disease-modifying antirheumatic drug such as methotrexate.

Switching to delayed-release prednisone reduced the duration of morning stiffness by roughly 50 minutes, and this benefit was maintained for the nine-month duration of the study.

These results provide additional evidence that taking delayed-release prednisone at bedtime reduces morning stiffness among RA patients who had been taking standard, immediate-release prednisone.

Reference: Rieke A, Holt R, Grahn A et al. Switching From Immediate Release (IR) Prednisone To Delayed Release (DR) Prednisone Improves Patient Reported Outcomes In Rheumatoid Arthritis (RA) Patients On Conventional Disease-Modifying Antirheumatic Drugs (DMARDs). Presented at the 2013 Annual Meeting of the American College of Rheumatology. San Diego, CA. October 26-30, 2013. Abstract 2265.

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